SANITY AND MADNESS, meeting 1 (out of 2)
- PKD
- Capgras syndrome (Ellis and Lewis)
- schizophrenia (Mitchell et al.)
"you would never know..."
Seeing his son from a distance, Steiner thought, You would never know to
look at him. The large, well-formed head, the curly hair, the handsome
features ...The boy was bent over, absorbed in some object which he held. A
geuninely good-loking boy, with eyes that shone sometimes mockingly,
sometimes with glee and excitement ... and such terrific coordination. The
wy he sprinted about, on the tips of his toes, as if dancing to some
unheard music, some tune from inside his own mind whose rhythms kept him
enthralled.
We are so pedestrian, compared to him, Steiner thought. Leaden. We creep
along like snails, while he dances and leaps, as if gravity does not have
the same influence on him as it does on us. Can he be made from some new
and different kind of atom?
"why wait?"
Suddenly it came to him that he should kill himself. The idea appeared in
his mind full blown, as if it had always been there, always a part of
him. Easy to do it, just crash the copter. He thought, I am goddamn tired
of being Norbert Steiner; I didn't ask to be Norbert Steiner or sell
blackmarket food or anything else. What is my reason for staying alive? I'm
not good with my hands, I can't fix or make anything; I can't use my mind,
either, I'm just a salesman. I'm tired of my wife's scorn because I can't
keep our water machinery going. - I'm tired of Otto who I had to hire
because I'm helpless even in my own business.
In fact, he thought, why wait until I can get back to the `copter?
Kindly Dad
Kindly Dad said, "Little Jackie, it seems to me you've got a might heavy
weight on your chest today. Am I right?"
"Today and every day." Jack clicked on his trouble-light and shone it up
into the works of the Teacher. The mechanism seemed to be moving along its
cycle properly so far.
"Maybe I can help you," Kindly Dad said. "Often it helps if an older, more
experienced person can sort of listen in on your troubles, can sort of
share them and make them lighter."
"O.K.," Jack agreed, sitting back on his haunces. "I'll play along; I'm
stuck here for three hours anyhow. You want me to go all the way back to
the beginning? To the episodes back on Earth when I worked for Corona
Corporation and had the occlusion?"
"Start wherever you like, Kindly Dad said graciously.
"Do you know what schizophrenia is, Kindly Dad?"
prosopagnosia and the Capgras delusion
prosopagnosia:
-
complete inability to recognize previously familiar faces
-
intact SCR (skin conductance response) and ERP (event-related
potential) correlates of recognition
Capgras delusion:
-
belief that some people (incl. family members), or pets, objects or
places
(cf. reduplicative paramnesia) have been replaced by
impostors or replicas
-
readiness to defend the belief (sometimes willingness to murder the
impostor)
a "box-and-arrows" model of face processing
SCR as an indicator of covert recognition
Capgras delusion as a mirror of prosopagnosia

According to a
dual-route model of visual recognition, one covert and
one overt:
- prosopagnosia = interruption of the overt route
- Capgras delusion = interruption of the covert route
- mean SCR to familiar faces and unfamiliar faces for three groups of subjects
-
SCR to repeated tones in Capgras
patients and normal
controls; the lack of familiar face differentiation in
Capgras patients cannot stem from general lack of SCR responsivity
gross neuroanatomy of face processing
- normal processing - both routes operational
- yellow: covert route
- red: overt route
- prosopagnosia: overt route interrupted
- Capgras delusion: covert route interrupted
a proposed model
-
an abnormality here will result in prosopagnosia
-
an abnormality here will lead to a loss of the affective response and
therefore to a Capgras delusion
-
an abnormality here will lead to a loss of SCR, but no delusions
[great for fooling a polygraph]
questions for future research
- [see p.155 of Ellis and Lewis]
- work out the implications of the possibility of the Capgras
delusion for the nature of self and its relationships to the world
...and now back to schizophrenia...
schizophrenia: a glossary
-
executive functions: planning, strategy selection, monitoring;
frontal-mediated
-
hypofrontality: reduced frontal lobe activation
-
negative symptoms: normal behaviors absent in schizophrenics
-
PFC: prefrontal cortex (the most anterior portion of the
frontal lobes)
-
positive symptoms: abnormal behaviors present in schizophrenics
-
psychotic disorder: a condition of impaired judgment and loss
of contact with reality
-
retrograde amnesia: memory loss for events prior to the onset
of disorder
-
schizophrenia: a psychotic disorder including
- a deterioration from premorbid levels of social and cognitive
functioning
- onset before midlife
- duration of at least 6 months
- psychotic symptoms (explained next)
symptoms of schizophrenia
"A key feature of the symptomatology of schizophrenia is pervasive cognitive
impairment."
DSM
IV
criteria:
- presence of two or more characteristic symptoms during acute
phase
- evidence of social/occupational dysfunction
- continuous signs of disturbance for at least 6 months
- exclusion of schizoaffective/mood disorders
- exclusion of cause by a substance or medical condition
- if history of developmental disorder, (1) must persist for at least a
month
positive and negative symptoms
- positive symptoms:
- hallucinations
- delusions
- bizarre behavior
- positive formal thought disorder (speech abnormalities)
- negative symptoms:
- affective flattening
- alogia
- avolition and apathy
- anhedonia and asociality
WCST (Wisconsin Card Sorting Test)
Towers of Hanoi
regions implicated in schizophrenia
"what's a little schizophrenia?"
"I sure appreciate your going in my place, Doc. You psychiatrists really
take a load off a man's back [...] ." He gazed with grateful awe at the man
before him, skilled in the social graces, capable of treading the narrow,
hazardous path of complex interpersonal relationships which had defeated so
many union members over the years.
"Don't worry any further about it," Dr. Glaub said. For after all, he
thought, what's a little schizophrenia? That is, you know, what you're
suffering from. I'll take the social pressure from you, and you can
continue in your chronic maladaptive state, at least for another few
months. Until the next overpowering social demand is made on your limited
capabilities....
Philip K. Dick, Martian Time-Slip, p.65
"The man was dead."
An then the hallucination, if it was that, happened. He saw the personnel
manager in a new light. The man was dead.
He saw, through the man's skin, his skeleton. It had been wired together,
the bones connected with fine copper wire. The organs, which had withered
away, were replaced by artificial components, kidney, heart, lungs
everything was made of plastic and stainless steel, all working in unison
but entirely without authentic life. The man's voice issued from a tape,
through an amplifier and speaker system.
[...] the entire structure was there to deceive others. To deceive him, Jack
Bohlen, in fact.
Philip K. Dick, Martian Time-Slip, p.79
"I know schizophrenia."
"Yes, Mister,"
Heliogabalus said. "I know schizophrenia; it is the savage
within the man."
"Sure, it's the reversion to primitive ways of thought, but so what, if you
can read the future?"
[...]
"You ever been psychoanalyzed, Helio?" Arnie [Kott] said to him, feeling cheerful, now.
"No, Mister. Entire psychoanalysis is a vainglorious foolishness."
"How zat, Helio?"
"Question they never deal with is, what to remold sick person like. There is
no what, Mister."
"I don't get you, Helio."
"Purpose of life is unknown, and hence way to be is hidden from the eyes of
living critters. Who can say if perhaps the schizophrenics are not correct?
Mister, they take a brave journey. They turn away from mere things, which
one may handle and turn to practical use; they turn inward to
meaning. There, the black-night-without-bottom lies, the pit. Who
can say if they will return? And if so, what will they be like, having
glimpsed meaning? I admire them."
Philip K. Dick, Martian Time-Slip, pp.92-93
"Could gubbish mean time?"

"There are so many bright, wonderful things he could see instead; why would
he want to see that?"
"Perhaps he has no choice," Jack said.
Gubbish, he thought. I wonder;
could
gubbish mean time? The force that to the boy means decay,
deterioration, destruction, and, at last, death? The force at work
everywhere, on everything in the universe.
Jack thought, And people talk about mental illness as an escape! He
shuddered. It was no escape; it was a narrowing, a contracting of life
into, at last, a moldering, dank tomb, a place where nothing came or went;
a place of total death.
Philip K. Dick, Martian Time-Slip, pp.144-145
Do
Not Go Gentle Into That Good Night
Do not go gentle into that good night,
Old age should burn and rave at close of day;
Rage, rage against the dying of the light.
Though wise men at their end know dark is right,
Because their words had forked no lightning they
Do not go gentle into that good night.
Good men, the last wave by, crying how bright
Their frail deeds might have danced in a green bay,
Rage, rage against the dying of the light.
Wild men who caught and sang the sun in flight,
And learn, too late, they grieved it on its way,
Do not go gentle into that good night.
Grave men, near death, who see with blinding sight
Blind eyes could blaze like meteors and be gay,
Rage, rage against the dying of the light.
And you, my father, there on the sad height,
Curse, bless, me now with your fierce tears, I pray.
Do not go gentle into that good night.
Rage, rage against the dying of the light.
Dylan Thomas
from Collected Poems 1934-1952
supplementary material
-
note: three journal articles on clinical aspects of
schizophrenia have been added to the sanity and
madness page
-
a discussion-target article on
schizophrenia and evolutionary psychology that appeared in the
Behavioral and Brain Sciences some time ago